Reactive oxygen metabolites inhibit spontaneous lymphatic contractions.
作者： D. C. Zawieja , S. T. Greiner , K. L. Davis , W. M. Hinds , H. J. Granger
DOI: 10.1152/AJPHEART.1991.260.6.H1935
关键词:
摘要: The effects of oxygen-derived free radicals on the contractile activity mesenteric collecting lymphatics were evaluated in anesthetized rat. Lymphatic contractions monitored before, during and after application oxyradicals. Contraction frequency (F), stroke volume (SV), ejection fraction (EF), contraction propagation (PC), lymph pump flow (LPF) determined from lymphatic diameter tracings. Oxyradicals generated using hypoxanthine xanthine oxidase. Exposure to oxyradicals inhibited pumping mechanism: 1) F fell 15.5 +/- 0.8 0.7 beats/min; 2) EF went 0.44 0.02 0.08 0.04; 3) PC dropped 92 2 56 8%; 4) LPF precipitously 41.0 5.2 0.4 nl/min. attenuated by superoxide dismutase, implicating anion as one predominant causative agents. We conclude that significantly inhibit this inhibition could be a factor contributing formation interstitial edema inflammation.
sci-hub.se 参考文章(21)
A E Taylor, The lymphatic edema safety factor: the role of edema dependent lymphatic factors (EDLF) Lymphology. ,vol. 23, pp. 111- 123 ,(1990)
J M McCord, I Fridovich, The Reduction of Cytochrome c by Milk Xanthine Oxidase Journal of Biological Chemistry. ,vol. 243, pp. 5753- 5760 ,(1968) , 10.1016/S0021-9258(18)91929-0
D.Neil Granger, Gianfranco Rutili, Joe M. McCord, Superoxide radicals in feline intestinal ischemia Gastroenterology. ,vol. 81, pp. 22- 29 ,(1981) , 10.1016/0016-5085(81)90648-X
I. Fridovich, Quantitative Aspects of the Production of Superoxide Anion Radical by Milk Xanthine Oxidase Journal of Biological Chemistry. ,vol. 245, pp. 4053- 4057 ,(1970) , 10.1016/S0021-9258(18)62884-4
D.Neil Granger, Marion Sennett, Pam McElearney, Aubrey E. Taylor, Effect of local arterial hypotension on cat intestinal capillary permeability. Gastroenterology. ,vol. 79, pp. 474- 480 ,(1980) , 10.1016/0016-5085(80)90372-8
H.J. Forman, J. Nelson, A.B. Fisher, Rat alveolar macrophages require NADPH for superoxide production in the respiratory burst. Effect of NADPH depletion by paraquat. Journal of Biological Chemistry. ,vol. 255, pp. 9879- 9883 ,(1980) , 10.1016/S0021-9258(18)43474-6
Volkhard Lindner, Helmut Heinle, Does the xanthine-xanthine oxidase system alter contractile behaviour of vascular smooth muscle? Pflügers Archiv: European Journal of Physiology. ,vol. 408, pp. 204- 206 ,(1987) , 10.1007/BF00581353
N G McHale, I C Roddie, The effect of transmural pressure on pumping activity in isolated bovine lymphatic vessels. The Journal of Physiology. ,vol. 261, pp. 255- 269 ,(1976) , 10.1113/JPHYSIOL.1976.SP011557
Christine A. Hanley, Radu M. Elias, Henry Z. Movat, Miles G. Johnston, Suppression of fluid pumping in isolated bovine mesenteric lymphatics by interleukin-1: interaction with prostaglandin E2. Microvascular Research. ,vol. 37, pp. 218- 229 ,(1989) , 10.1016/0026-2862(89)90039-3
K. Prasad, J. Kalra, W.P. Chan, A.K. Chaudhary, Effect of oxygen free radicals on cardiovascular function at organ and cellular levels American Heart Journal. ,vol. 117, pp. 1196- 1202 ,(1989) , 10.1016/0002-8703(89)90396-7