Ciliary neurotrophic factor constitutively expressed in the nervous system of transgenic mice protects embryonic dorsal root ganglion neurons from apoptosis.
作者： Emanuela Tolosano , Miguel Angel Cutufia , Emilio Hirsch , Guglielmo Stefanuto , Samuele Voyron
DOI: 10.1111/J.1460-9568.1996.TB01236.X
关键词:
摘要: Ciliary neurotrophic factor (CNTF) is a potent survival for several neuronal populations. It expressed postnatally by Schwann cells in the peripheral nervous system and some glial central system. We used promoter of neurofilament light chain gene to produce transgenic mice that express CNTF neurons from beginning differentiation. These animals may represent suitable model identify cell types responsive vivo study mechanism action this factor. show dorsal root ganglion expressing are protected apoptosis during embryonic development: 40% these undergo between day 12.5 postnatal 5 whereas 60% do so control animals. However, protection does not result an increase total number at end development. discuss our results with regard potentialities significance programmed death
sci-hub.se 参考文章(50)
Y Arakawa, M Sendtner, H Thoenen, Survival effect of ciliary neurotrophic factor (CNTF) on chick embryonic motoneurons in culture: comparison with other neurotrophic factors and cytokines. The Journal of Neuroscience. ,vol. 10, pp. 3507- 3515 ,(1990) , 10.1523/JNEUROSCI.10-11-03507.1990
Jörg Mey, Solon Thanos, Intravitreal injections of neurotrophic factors support the survival of axotomized retinal ganglion cells in adult rats in vivo Brain Research. ,vol. 602, pp. 304- 317 ,(1993) , 10.1016/0006-8993(93)90695-J
Uwe Ernsberger, Michael Sendtner, Hermann Rohrer, Proliferation and differentiation of embryonic chick sympathetic neurons: effects of ciliary neurotrophic factor. Neuron. ,vol. 2, pp. 1275- 1284 ,(1989) , 10.1016/0896-6273(89)90312-7
Mario Rende, David Muir, Erkki Ruoslahti, Theo Hagg, Silvio Varon, Marston Manthorpe, Immunolocalization of ciliary neuronotrophic factor in adult rat sciatic nerve. Glia. ,vol. 5, pp. 25- 32 ,(1992) , 10.1002/GLIA.440050105
Alan B. Sachs, Messenger RNA degradation in eukaryotes Cell. ,vol. 74, pp. 413- 421 ,(1993) , 10.1016/0092-8674(93)80043-E
T. Hagg, S. Varon, Ciliary neurotrophic factor prevents degeneration of adult rat substantia nigra dopaminergic neurons in vivo Proceedings of the National Academy of Sciences of the United States of America. ,vol. 90, pp. 6315- 6319 ,(1993) , 10.1073/PNAS.90.13.6315
ANTONIO MIGHELI, PAOLA CAVALLA, SILVIA MARINO, DAVIDE SCHIFFER, A Study of Apoptosis in Normal and Pathologic Nervous Tissue After In situ End-Labeling of DNA Strand Breaks Journal of Neuropathology and Experimental Neurology. ,vol. 53, pp. 606- 616 ,(1994) , 10.1097/00005072-199411000-00008
Cynthia Lance-Jone, Motoneuron cell death in the developing lumbar spinal cord of the mouse Brain Research. ,vol. 256, pp. 473- 479 ,(1982) , 10.1016/0165-3806(82)90192-4
R. E. Clatterbuck, D. L. Price, V. E. Koliatsos, Ciliary neurotrophic factor prevents retrograde neuronal death in the adult central nervous system. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 90, pp. 2222- 2226 ,(1993) , 10.1073/PNAS.90.6.2222
R. Oppenheim, D Prevette, Q. Yin, F Collins, J MacDonald, Control of embryonic motoneuron survival in vivo by ciliary neurotrophic factor. Science. ,vol. 251, pp. 1616- 1618 ,(1991) , 10.1126/SCIENCE.2011743