Apoptosis. A Bad kinase makes good.

作者: Thomas F. Franke , Lewis C. Cantley

DOI: 10.1038/36442

关键词:

摘要: The balance between cell survival and programmed death (apoptosis) is important in animal growth development. Several new reports now unravel the intricate set of instructions one pathway that promotes survival. central players are an enzyme called Akt, a protein Bad, which (as its name suggests) tells cells to die, Bcl-xL, factor. Activated Akt adds phosphate group then dissociates from complex with Bcl-xL. latter free halt activity enzymes caspases, cells' executioners.

参考文章(1)
Michael O. Hengartner, Apoptosis CED-4 is a stranger no more Nature. ,vol. 388, pp. 714- 715 ,(1997) , 10.1038/41873