The alveolar type I cells : the new knight of the alveolus?

摘要: Until recently our knowledge of the function and regulation alveolar type I cells has been relatively modest. They cover 95% surface form a tight epithelial barrier along with II that helps keep alveoli dry. It is also recognized its special morphological characteristics are perfectly designed for efficient gas exchange between alveolus pulmonary capillaries. Much more known about cells, which remaining 5% surface. Mason & Williams (1977) described as ‘crenated tower’ defending alveolus. This concept since supported by extensive data demonstrating cell multiple functions in addition to traditionally role surfactant secretion (Fehrenbach, 2001). now well accepted plays an important fluid balance across actively involved ion transport epithelium (Berthiaume et al. 1999). repair process following injury, it can proliferate differentiate into Finally, play major immunological defence alveolus, secreting various cytokines recruitment inflammatory lung