Mitochondrial bound type II hexokinase: a key player in the growth and survival of many cancers and an ideal prospect for therapeutic intervention.

作者: Peter L Pedersen , Saroj Mathupala , Annette Rempel , J.F Geschwind , Young Hee Ko

DOI: 10.1016/S0005-2728(02)00248-7

关键词:

摘要: Despite more than 75 years of research by some of the greatest scientists in the world to conquer cancer, the clear winner is still cancer. This is reflected particularly by liver cancer that …

参考文章(83)
Ernesto Bustamante, Harold P. Morris, Peter L. Pedersen, Hexokinase: the direct link between mitochondrial and glycolytic reactions in rapidly growing cancer cells. Advances in Experimental Medicine and Biology. ,vol. 92, pp. 363- 380 ,(1978) , 10.1007/978-1-4615-8852-8_15
Irwin A. Rose, Jessie V.B. Warms, Mitochondrial hexokinase. Release, rebinding, and location. Journal of Biological Chemistry. ,vol. 242, pp. 1635- 1645 ,(1967) , 10.1016/S0021-9258(18)96139-9
P V Viitanen, P J Geiger, S Erickson-Viitanen, S P Bessman, Evidence for functional hexokinase compartmentation in rat skeletal muscle mitochondria. Journal of Biological Chemistry. ,vol. 259, pp. 9679- 9686 ,(1984) , 10.1016/S0021-9258(17)42754-2
Constance A. Griffin, Peter L. Pedersen, Anita L. Hawkins, Saroj P. Mathupala, Annette Rempel, Glucose Catabolism in Cancer Cells: Amplification of the Gene Encoding Type II Hexokinase Cancer Research. ,vol. 56, pp. 2468- 2471 ,(1996)
Irwin A. Rose, Jessie V.B. Warms, Stability of hexokinase II in Vitro and in ascites tumor cells Archives of Biochemistry and Biophysics. ,vol. 213, pp. 625- 634 ,(1982) , 10.1016/0003-9861(82)90592-6
Siby Sebastian, Seby Edassery, John E. Wilson, The human gene for the type III isozyme of hexokinase: structure, basal promoter, and evolution. Archives of Biochemistry and Biophysics. ,vol. 395, pp. 113- 120 ,(2001) , 10.1006/ABBI.2001.2584
Saroj P. Mathupala, Curt Heese, Peter L. Pedersen, Glucose Catabolism in Cancer Cells Journal of Biological Chemistry. ,vol. 272, pp. 22776- 22780 ,(1997) , 10.1074/JBC.272.36.22776
Anne M. Mulichak, John E. Wilson, Kaillathe Padmanabhan, R. Michael Garavito, The structure of mammalian hexokinase-1 Nature Structural Biology. ,vol. 5, pp. 555- 560 ,(1998) , 10.1038/811
Tomas Johansson, Jean-Marc Berrez, B.Dean Nelson, Evidence that transcription of the hexokinase gene is increased in a rapidly growing rat hepatoma Biochemical and Biophysical Research Communications. ,vol. 133, pp. 608- 613 ,(1985) , 10.1016/0006-291X(85)90948-9