Pediatric and Adult Osteosarcoma: Comparisons and Contrasts in Presentation and Therapy

摘要: Most data on osteosarcoma is derived from pediatric studies. Although the majority of adult patients with are young adults, who might be treated in a similar fashion, experience slightly older population helpful directing therapy. We series 123 extremities adriamycin and cisplatin as induction Adriamycin was infused intravenously at 90 mg/m2 over 96 h. Cisplatin intra-arterially 120–160 2–24 Sequential addition methotrexate plus ifosfamide subsequent cohorts improved continuous relapse-free survival poor responders such that overall improvement noted group where therapy modified by adding both agents to those <90% tumor necrosis. Patients chondroblastic necrosis had trend towards compared other conventional osteosarcoma. Histologic variants except telangiectatic worse prognosis than The variants, especially dedifferentiated parosteal well-differentiated intraosseous more common adults children, accounting for some inferior adults. Older obviously cannot tolerate doses given children again decreasing chances successful treatment. secondary often much many osteosarcomas pelvis jaw. These tumors tend less responsive. An attempt intensify poor-prognosis three-drug regimen adriamycin, cisplatin, peripheral stem cell support unsuccessful prolonging survival, we no longer use approach.