Description of USP12 nuclear export sequence
作者： Jose Antonio Rodriguez
关键词:
摘要: In PNAS, Jahan et al. (1) describe a new role for the ubiquitin-specific protease 12 (USP12) deubiquitinase in T-cell receptor (TCR) signaling. Among other findings, authors report that USP12 is exported from nucleus to cytosol upon TCR activation. Although experimental evidence they provide consistent with this model, I believe some of their results would require more detailed description support claims better.
sci-hub.se 参考文章(5)
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Akhee S. Jahan, Maxime Lestra, Lee Kim Swee, Ying Fan, Mart M. Lamers, Fikadu G. Tafesse, Christopher S. Theile, Eric Spooner, Roberto Bruzzone, Hidde L. Ploegh, Sumana Sanyal, Usp12 stabilizes the T-cell receptor complex at the cell surface during signaling Proceedings of the National Academy of Sciences of the United States of America. ,vol. 113, pp. 201521763- ,(2016) , 10.1073/PNAS.1521763113