Natural killer cell activity during the course of disease in patients with Hodgkin's disease.

作者: Irena Frydecka

DOI: 10.1002/1097-0142(19851215)56:12<2799::AID-CNCR2820561215>3.0.CO;2-W

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摘要: Natural killer (NK) activity was investigated in 61 patients with Stage III and IV Hodgkin's disease during the course of 30 healthy age- sex-matched volunteers. The mean NK significantly lower (P less than 0.001) untreated active phase treatment, compared controls. There a similar value normal subjects, clinical remission. correlated response to therapy. In responding increasing, reaching range not therapy showed gradual decrease disease. These results suggest that study function might offer helpful tool following efficacy therapy, as well for monitoring cancer from an immunologic viewpoint.

参考文章(48)
J. M. Slaney, B. D. Williams, P. L. Amlot, B. Pussell, Correlation between immune complexes and prognostic factors in Hodgkin's disease Clinical and Experimental Immunology. ,vol. 31, pp. 166- 173 ,(1978)
Philip Ruben, Lloyd F. Craver, Thomas C. Hall, Robert J. Lukes, Henry Rappaport, Report of the Nomenclature Committee Cancer Research. ,vol. 26, pp. 1311- 1311 ,(1966)
R B Herberman, J R Ortaldo, T Timonen, S O Sharrow, Determination of surface antigens on highly purified human NK cells by flow cytometry with monoclonal antibodies. Journal of Immunology. ,vol. 127, pp. 2401- 2409 ,(1981)
Klas Kärre, Mona Hansson, Birger Andersson, Rolf Kiessling, John Roder, Pekka Häyry, Natural NK-Cell Targets in the Mouse Thymus: Characteristics of the Sensitive Cell Population Journal of Immunology. ,vol. 123, pp. 765- 771 ,(1979)
Mitsuo Takasugi, Julie Takasugi, Annie Ramseyer, Decline of natural nonselective cell-mediated cytotoxicity in patients with tumor progression. Cancer Research. ,vol. 37, pp. 413- 418 ,(1977)
Mona Hansson, George Klein, Rolf Kiessling, Klas Karre Tibor Bakacs, Intra- and Interspecies Reactivity of Human and Mouse Natural Killer (NK) Cells Journal of Immunology. ,vol. 121, pp. 6- 12 ,(1978)
Edgar G. Engleman, Claudia J. Benike, Richard T. Hoppe, Henry S. Kaplan, F. Ralph Berberich, Autologous Mixed Lymphocyte Reaction in Patients with Hodgkin's Disease: EVIDENCE FOR A T CELL DEFECT Journal of Clinical Investigation. ,vol. 66, pp. 149- 158 ,(1980) , 10.1172/JCI109828
Anne L. Rassiga-Pidot, O. Ross McIntyre, In Vitro Leukocyte Interferon Production in Patients with Hodgkin's Disease Cancer Research. ,vol. 34, pp. 2995- 3002 ,(1974)
Henry S. Kaplan, Maurice Tubiana, Paul P. Carbone, David W. Smithers, Karl Musshoff, Report of the Committee on Hodgkin's Disease Staging Classification. Cancer Research. ,vol. 31, pp. 1860- 1861 ,(1971)