Intra- and Interspecies Reactivity of Human and Mouse Natural Killer (NK) Cells

摘要: Natural killer (NK) cells can kill certain syngeneic, allogeneic and xenogeneic tumor targets in short-term 51 Cr release assays. In the present study, intra- interspecies NK activity was analyzed. Ten mouse five human tissue culture lines were used. direct cytolytic assays with spleen or PBL effectors, intraspecies much stronger than reactivity, as a rule. A obtained, anti-human (M α H) anti-mouse (H M) combinations. H M system, associated same type of PBL-derived non-B-non-T cell fraction system. The nature has been demonstrated previously. Nonlabeled allowed to compete isotope-labeled tests. NK-sensitive species superior competitors both assay, competing ability tumors varied, depending on genotype effector cells. None tested competed effectively strain CBA effectors but some showed competition C57BL effectors. strong seen two 10 tested.