ANALYSIS OF DIFFERENTIATION EVENTS CAUSING CHANGES IN NK CELL TUMOR-TARGET SENSITIVITY
作者： Thomas Tötterman , Kenneth Nilsson , Magnus Gidlund , Masato Nose , Inger Axberg
DOI: 10.1016/B978-0-12-341360-4.50113-X
关键词: Cell culture 、 Cancer research 、 Biology 、 Interleukin 21 、 Myeloid leukemia 、 In vitro 、 Cell 、 Homologous chromosome 、 Lymphokine-activated killer cell 、 Chronic lymphocytic leukemia 、 Immunology
摘要: Publisher Summary This chapter analyzes differentiation events causing changes in natural killer (NK) cell tumor–target sensitivity. The presents data obtained the analysis of freshly isolated human chronic lymphocytic leukemia (CCL) cells and a murine myeloid line undergoing induced controlled vitro. study described analyzed way which induction to altered NK sensitivity tumor population its ability be lysed by homologous or xenogeneic effector whether alteration affected competing capacity such when known target were used. Freshly from B-CLL patients can, certain cases, differentiate vitro, if treated with phorbol ester 12-0-tetradecanoyl-13-phorbolacetate (TPA). total material included 18 tested at 35 different occasions during time period months. A substantial increase susceptibility was noted 19 cases (responders). peaked third day culture. No change background shown cultured absence TPA.
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