The immune system vs. Pseudomonas aeruginosa biofilms

摘要: Ilya Metchnikoff and Paul Ehrlich were awarded the Nobel price in 1908. Since then, numerous studies have unraveled a multitude of mechanistically different immune responses to intruding microorganisms. However, vast majority these studies, underlying infectious agents appeared planktonic state. Accordingly, much less is known about presence biofilm-based infections (which probably also due relatively short period time which response biofilms has been studied). Nevertheless, more recent vivo vitro revealed both innate as well adaptive biofilms. On other hand, measures launched by biofilm bacteria achieve protection against various demonstrated. Whether particular exist remains be firmly established. because are often persistent (or chronic), an odd situation appears with simultaneous activation arms host response, neither can eliminate pathogen, but instead, synergy, causes collateral tissue damage. Although present review on system vs. focused Pseudomonas aeruginosa (mainly this most thoroughly studied), many same mechanisms seen generated