Osteoinductive biomaterials for medical implantation.

摘要: The search for the ideal implant material continues since presently available implants all have significant drawbacks. This paper reviews three studies that we recently completed with bone-inducing implants. Long-term clinical follow-up of 75 allogeneic demineralized bone showed an average degree resorption 49%. Implants used dorsal nasal augmentation 50.7%, increasing to 82.5% after a 24-month follow-up. efficacy is dependent on many factors including site implantation, method preparation, etc. Transforming growth factor-beta 1 (TGF-beta 1) regulator formation. We combined recombinant TGF-beta powder in rabbit facial model. At 6 weeks, there was evidence increased formation containing 1. Even though can increase implants, overall activity these seems be suboptimal. Osteoinductive factor extract (OFE) partially purified preparation has been shown form when implanted into rats. Using collagen/ceramic carrier, OFE 21 d, histomorphometry revealed numerous osteoblasts and osteoinductive preparations such as probably due Bone Morphogenetic Protein-2A (BMP-2A), which induce its form. Recombinant DNA methodology provides technology necessary produce molecules their homogeneous form, permitting evaluation free contaminants. Finally, carrier must devised permit safe effective delivery factors.