Food reward in the obese and after weight loss induced by calorie restriction and bariatric surgery

摘要: Increased availability of tasty, energy-dense foods has been blamed as a major factor in the alarmingly high prevalence obesity, diabetes, and metabolic disease, even young age. A heated debate started to whether some these should be considered addictive, similar drugs alcohol. One main arguments for food addiction is similarity neural mechanisms underlying reward generation by drugs. Here, we will discuss how intake can generate behavioral functions are different obese subjects. Because most studies simply compare lean subjects, it not clear predisposing differences cause overeating weight gain, or repeated exposure secondary effects state alter functions. While both rodents humans demonstrate preexisting obese, rodent models using calorie restriction gastric bypass surgery show that reversible loss therefore state.