ESTIMATION OF LIPOPHILICITY AND RETENTION BEHAVIOR OF SOME ALPHA ADRENERGIC AND IMIDAZOLINE RECEPTOR LIGANDS USING RP-TLC
作者： Musbah Salem Mohamed Shenger , Slavica Filipic , Katarina Nikolic , Danica Agbaba
DOI: 10.1080/10739149.2014.906880
关键词:
摘要: The chromatographic behavior of 16 alpha adrenergic and imidazoline receptor ligands has been studied by reversed-phase thin-layer chromatography (RP-TLC) on RP-18 CN stationary phases. Retention constant was determined for all tested compounds in three different systems: methanol–water/RP-18, tetrahydrofuran–ammonia-water/RP-18, tetrahydrofuran–ammonia–water/CN. Good correlations between hydrophobic parameters calculated log P values were obtained the system tetrahydrofuran–ammonia–water both Experimentally computed molecular examined further used quantitative structure–retention relationship (QSRR) study, order to determine most important properties governing retention. QSRR modeling performed with use partial least squares regression, predictive performances developed models cross-validation externa...
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