Chromosomal rearrangements involving the NTRK1 gene in colorectal carcinoma.

摘要: Chromosomal rearrangements of the NTRK1 gene, which encodes high affinity nerve growth factor receptor (tropomyosin related kinase, TRKA), have been observed in several epithelial cancers, such as colon cancer, papillary thyroid carcinoma or non small cell lung cancer. The various fusions described so far lead to constitutive activation TRKA kinase activity and are oncogenic. We further investigated here existence frequency gene colorectal Using immunohistochemistry quantitative reverse transcriptase PCR, we analyzed a series human cancers. identified two positive cases over 408, with chromosomal rearrangements. One these is TPM3-NTRK1 fusion already while second one TPR-NTRK1 never this type These findings confirm that translocations recurring events although occurring at low (around 0.5%).