Oncogenic and drug-sensitive NTRK1 rearrangements in lung cancer.
作者： Doron Lipson , Philip J Stephens , Vince A Miller , Marileila Varella-Garcia , Pasi A Jänne
DOI: 10.1038/NM.3352
关键词:
摘要: We identified new gene fusions in patients with lung cancer harboring the kinase domain of NTRK1 that encodes high-affinity nerve growth factor receptor (TRKA protein). Both MPRIP-NTRK1 and CD74-NTRK1 lead to constitutive TRKA activity are oncogenic. Treatment cells expressing inhibitors inhibited autophosphorylation cell growth. Tumor samples from 3 91 (3.3%) without known oncogenic alterations assayed by next-generation sequencing or fluorescence situ hybridization demonstrated evidence fusions.
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