Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies

Daisy Wing-Sze Wong, Elaine Lai-Han Leung, Sunny Kit-Man Wong, Vicky Pui-Chi Tin, Alan Dart-Loon Sihoe, Lik-Cheung Cheng, Joseph Siu-Kie Au, Lap-Ping Chung, Maria Pik Wong, A novel KIF5B-ALK variant in nonsmall cell lung cancer. Cancer. ,vol. 117, pp. 2709- 2718 ,(2011) , 10.1002/CNCR.25843

Peter L. Toogood, Patricia J. Harvey, Joseph T. Repine, Derek J. Sheehan, Scott N. VanderWel, Hairong Zhou, Paul R. Keller, Dennis J. McNamara, Debra Sherry, Tong Zhu, Joanne Brodfuehrer, Chung Choi, Mark R. Barvian, David W. Fry, Discovery of a potent and selective inhibitor of cyclin-dependent kinase 4/6. Journal of Medicinal Chemistry. ,vol. 48, pp. 2388- 2406 ,(2005) , 10.1021/JM049354H

S. A. Forbes, N. Bindal, S. Bamford, C. Cole, C. Y. Kok, D. Beare, M. Jia, R. Shepherd, K. Leung, A. Menzies, J. W. Teague, P. J. Campbell, M. R. Stratton, P. A. Futreal, COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer. Nucleic Acids Research. ,vol. 39, pp. 945- 950 ,(2011) , 10.1093/NAR/GKQ929

Ingrid E. Wertz, Saritha Kusam, Cynthia Lam, Toru Okamoto, Wendy Sandoval, Daniel J. Anderson, Elizabeth Helgason, James A. Ernst, Mike Eby, Jinfeng Liu, Lisa D. Belmont, Joshua S. Kaminker, Karen M. O’Rourke, Kanan Pujara, Pawan Bir Kohli, Adam R. Johnson, Mark L. Chiu, Jennie R. Lill, Peter K. Jackson, Wayne J. Fairbrother, Somasekar Seshagiri, Mary J. C. Ludlam, Kevin G. Leong, Erin C. Dueber, Heather Maecker, David C. S. Huang, Vishva M. Dixit, Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7 Nature. ,vol. 471, pp. 110- 114 ,(2011) , 10.1038/NATURE09779

Jeffrey A Engelman, Liang Chen, Xiaohong Tan, Katherine Crosby, Alexander R Guimaraes, Rabi Upadhyay, Michel Maira, Kate McNamara, Samanthi A Perera, Youngchul Song, Lucian R Chirieac, Ramneet Kaur, Angela Lightbown, Jessica Simendinger, Timothy Li, Robert F Padera, Carlos García-Echeverría, Ralph Weissleder, Umar Mahmood, Lewis C Cantley, Kwok-Kin Wong, Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers Nature Medicine. ,vol. 14, pp. 1351- 1356 ,(2008) , 10.1038/NM.1890

Yongchao Wang, Warren Fiskus, Daniel G. Chong, Kathleen M. Buckley, Kavita Natarajan, Rekha Rao, Atul Joshi, Ramesh Balusu, Sanjay Koul, Jianguang Chen, Andrew Savoie, Celalettin Ustun, Anand P. Jillella, Peter Atadja, Ross L. Levine, Kapil N. Bhalla, Cotreatment with panobinostat and JAK2 inhibitor TG101209 attenuates JAK2V617F levels and signaling and exerts synergistic cytotoxic effects against human myeloproliferative neoplastic cells Blood. ,vol. 114, pp. 5024- 5033 ,(2009) , 10.1182/BLOOD-2009-05-222133

A. Fusco, M. Grieco, M. Santoro, M. T. Berlingieri, S. Pilotti, M. A. Pierotti, G. Della Porta, G. Vecchio, A new oncogene in human thyroid papillary carcinomas and their lymph-nodal metastases Nature. ,vol. 328, pp. 170- 172 ,(1987) , 10.1038/328170A0

Manabu Soda, Young Lim Choi, Munehiro Enomoto, Shuji Takada, Yoshihiro Yamashita, Shunpei Ishikawa, Shin-ichiro Fujiwara, Hideki Watanabe, Kentaro Kurashina, Hisashi Hatanaka, Masashi Bando, Shoji Ohno, Yuichi Ishikawa, Hiroyuki Aburatani, Toshiro Niki, Yasunori Sohara, Yukihiko Sugiyama, Hiroyuki Mano, None, Identification of the transforming EML4–ALK fusion gene in non-small-cell lung cancer Nature. ,vol. 448, pp. 561- 566 ,(2007) , 10.1038/NATURE05945

Federica Di Nicolantonio, Sabrina Arena, Josep Tabernero, Stefano Grosso, Francesca Molinari, Teresa Macarulla, Mariangela Russo, Carlotta Cancelliere, Davide Zecchin, Luca Mazzucchelli, Takehiko Sasazuki, Senji Shirasawa, Massimo Geuna, Milo Frattini, José Baselga, Margherita Gallicchio, Stefano Biffo, Alberto Bardelli, Deregulation of the PI3K and KRAS signaling pathways in human cancer cells determines their response to everolimus Journal of Clinical Investigation. ,vol. 120, pp. 2858- 2866 ,(2010) , 10.1172/JCI37539

N TURNER, A TUTT, A ASHWORTH, Targeting the DNA repair defect of BRCA tumours. Current Opinion in Pharmacology. ,vol. 5, pp. 388- 393 ,(2005) , 10.1016/J.COPH.2005.03.006