Deregulation of the PI3K and KRAS signaling pathways in human cancer cells determines their response to everolimus

作者: Federica Di Nicolantonio , Sabrina Arena , Josep Tabernero , Stefano Grosso , Francesca Molinari

DOI: 10.1172/JCI37539

关键词:

摘要: Personalized cancer medicine is based on the concept that targeted therapies are effective on subsets of patients whose tumors carry specific molecular alterations. Several mammalian …

参考文章(39)
Federica Di Nicolantonio, Sabrina Arena, Margherita Gallicchio, Alberto Bardelli, Isogenic mutant human cells: A new tool for personalized cancer medicine Cell Cycle. ,vol. 9, pp. 20- 21 ,(2010) , 10.4161/CC.9.1.10474
D. Xing, S. Orsulic, A genetically defined mouse ovarian carcinoma model for the molecular characterization of pathway-targeted therapy and tumor resistance. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 102, pp. 6936- 6941 ,(2005) , 10.1073/PNAS.0502256102
Sandrine Faivre, Guido Kroemer, Eric Raymond, Current development of mTOR inhibitors as anticancer agents Nature Reviews Drug Discovery. ,vol. 5, pp. 671- 688 ,(2006) , 10.1038/NRD2062
Audrey Carrière, Marie Cargnello, Louis-André Julien, Huanhuan Gao, Éric Bonneil, Pierre Thibault, Philippe P. Roux, Oncogenic MAPK Signaling Stimulates mTORC1 Activity by Promoting RSK-Mediated Raptor Phosphorylation Current Biology. ,vol. 18, pp. 1269- 1277 ,(2008) , 10.1016/J.CUB.2008.07.078
Philippe P. Roux, David Shahbazian, Hieu Vu, Marina K. Holz, Michael S. Cohen, Jack Taunton, Nahum Sonenberg, John Blenis, RAS/ERK Signaling Promotes Site-specific Ribosomal Protein S6 Phosphorylation via RSK and Stimulates Cap-dependent Translation Journal of Biological Chemistry. ,vol. 282, pp. 14056- 14064 ,(2007) , 10.1074/JBC.M700906200
Xiaoju Max Ma, John Blenis, Molecular mechanisms of mTOR-mediated translational control Nature Reviews Molecular Cell Biology. ,vol. 10, pp. 307- 318 ,(2009) , 10.1038/NRM2672
Stefano Grosso, Viviana Volta, Leonardo A. Sala, Marina Vietri, Pier Carlo Marchisio, Dorit Ron, Stefano Biffo, PKCβII modulates translation independently from mTOR and through RACK1 Biochemical Journal. ,vol. 415, pp. 77- 85 ,(2008) , 10.1042/BJ20080463
Xuerong Wang, Ping Yue, Young Ae Kim, Haian Fu, Fadlo R. Khuri, Shi-Yong Sun, Enhancing Mammalian Target of Rapamycin (mTOR)–Targeted Cancer Therapy by Preventing mTOR/Raptor Inhibition-Initiated, mTOR/Rictor-Independent Akt Activation Cancer Research. ,vol. 68, pp. 7409- 7418 ,(2008) , 10.1158/0008-5472.CAN-08-1522
S Shirasawa, M Furuse, N Yokoyama, T Sasazuki, Altered growth of human colon cancer cell lines disrupted at activated Ki-ras Science. ,vol. 260, pp. 85- 88 ,(1993) , 10.1126/SCIENCE.8465203
X Wan, B Harkavy, N Shen, P Grohar, L J Helman, Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism. Oncogene. ,vol. 26, pp. 1932- 1940 ,(2007) , 10.1038/SJ.ONC.1209990