A new oncogene in human thyroid papillary carcinomas and their lymph-nodal metastases

摘要: Using DNA transfection analysis on NIH 3T3 cells, activated human oncogenes have been isolated from a variety of fresh solid tumours. Thyroid neoplasias show wide range lesions varying slowly progressive well-differentiated tumours to anaplastic highly malignant neoplasms. Therefore they represent an attractive model investigate the role oncogene activation in different stages neoplastic state. Here we report detection transforming activity DNAs extracted five thyroid papillary carcinomas and two their respective lymph-nodal metastases.