Targeting the DNA repair defect of BRCA tumours.
作者： N TURNER , A TUTT , A ASHWORTH
DOI: 10.1016/J.COPH.2005.03.006
关键词: Allele 、 Function (biology) 、 Genetics 、 Dna breaks 、 Functional role 、 Recombination 、 DNA repair 、 Cancer research 、 DNA damage 、 Homologous recombination 、 Biology
摘要: Carriers of heterozygous mutations in BRCA1 or BRCA2 are strongly predisposed to breast and ovarian cancers. Cancers arising these individuals have consistently lost the wild-type allele during tumour progression, therefore deficient function. Both proteins been implicated repair double-strand DNA breaks by homologous recombination. This functional role could be exploited treatment BRCA-deficient cancers targeting tumours with drugs that create damage highly reliant on for repair.
core.ac.uk
elsevier.com
sci-hub.se 参考文章(50)
Huichen Wang, Zhao-Chong Zeng, Tu-Anh Bui, Steven J DiBiase, Wei Qin, Fen Xia, Simon N Powell, George Iliakis, None, Nonhomologous end-joining of ionizing radiation-induced DNA double-stranded breaks in human tumor cells deficient in BRCA1 or BRCA2. Cancer Research. ,vol. 61, pp. 270- 277 ,(2001)
Nicholas Turner, Andrew Tutt, Alan Ashworth, Hallmarks of 'BRCAness' in sporadic cancers Nature Reviews Cancer. ,vol. 4, pp. 814- 819 ,(2004) , 10.1038/NRC1457
Wen Hwa Lee, Phang Lang Chen, Thomas G. Boyer, Qing Zhong, Deficient nonhomologous end-joining activity in cell-free extracts from Brca1-null fibroblasts. Cancer Research. ,vol. 62, pp. 3966- 3970 ,(2002)
J. Couzin, Choices-and Uncertainties-for Women With BRCA Mutations Science. ,vol. 302, pp. 592- 592 ,(2003) , 10.1126/SCIENCE.302.5645.592
Haijuan Yang, Qiubai Li, Jie Fan, William K. Holloman, Nikola P. Pavletich, The BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA-ssDNA junction. Nature. ,vol. 433, pp. 653- 657 ,(2005) , 10.1038/NATURE03234
Andrew Tutt, David Bertwistle, Janet Valentine, Anastasia Gabriel, Sally Swift, Gillian Ross, Carol Griffin, John Thacker, Alan Ashworth, Mutation in Brca2 stimulates error‐prone homology‐directed repair of DNA double‐strand breaks occurring between repeated sequences The EMBO Journal. ,vol. 20, pp. 4704- 4716 ,(2001) , 10.1093/EMBOJ/20.17.4704
Hannah Farmer, Nuala McCabe, Christopher J. Lord, Andrew N. J. Tutt, Damian A. Johnson, Tobias B. Richardson, Manuela Santarosa, Krystyna J. Dillon, Ian Hickson, Charlotte Knights, Niall M. B. Martin, Stephen P. Jackson, Graeme C. M. Smith, Alan Ashworth, Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy Nature. ,vol. 434, pp. 917- 921 ,(2005) , 10.1038/NATURE03445
Alan R. Lehmann, The role of SMC proteins in the responses to DNA damage DNA Repair. ,vol. 4, pp. 309- 314 ,(2005) , 10.1016/J.DNAREP.2004.07.009
Andrew Tutt, Alan Ashworth, The relationship between the roles of BRCA genes in DNA repair and cancer predisposition Trends in Molecular Medicine. ,vol. 8, pp. 571- 576 ,(2002) , 10.1016/S1471-4914(02)02434-6
D.Paul Harkin, James M Bean, David Miklos, Young-Han Song, Vivi B Truong, Christoph Englert, Fred C Christians, Leif W Ellisen, Shyamala Maheswaran, Jonathan D Oliner, Daniel A Haber, INDUCTION OF GADD45 AND JNK/SAPK-DEPENDENT APOPTOSIS FOLLOWING INDUCIBLE EXPRESSION OF BRCA1 Cell. ,vol. 97, pp. 575- 586 ,(1999) , 10.1016/S0092-8674(00)80769-2