Unique Genetic and Survival Characteristics of Invasive Mucinous Adenocarcinoma of the Lung.

摘要: Introduction: Invasive mucinous adenocarcinoma is a unique histologic subtype of lung cancer, and our knowledge its genetic clinical characteristics rapidly evolving. Here, we present next- generation sequencing analysis nucleotide variant fusion events along with follow-up in series adenocarcinoma. Methods: We collected 72 adenocarcinomas from the United States Korea. All had been previously assessed for KRAS EGFR mutations. For wild-type cases ( n = 30), performed deep targeted next-generation gene fusions variants correlated survival other features. Results: As expected, mutations were most common alteration found (63% cases); however, distribution position alterations was more similar to that observed gastrointestinal tumors than tumors. Within -negative cases, numerous potentially targetable mutations, including CD74-NRG1 , VAMP2-NRG1 TRIM4-BRAF TPM3-NTRK1 EML4-ALK ERBB2 BRAF PIK3CA Unexpectedly, only two TP53 mutation, which much lower general. The overall mutation burden low histologically confirmed public Cancer Genome Atlas exome data set, regardless smoking history, suggesting link between status There no significant difference recurrence-free stage-matched nonmucinous adenocarcinomas. It notable all recurrence sites lungs completely resected cases. Conclusions: Our suggest typified by (1) frequent growing list fusions, but rare (2) overall, (3) tumors, recurrences limited lungs.