Retrospective Multicenter Study Investigating the Role of Targeted Next-Generation Sequencing of Selected Cancer Genes in Mucinous Adenocarcinoma of the Lung

摘要: Abstract Introduction Mucin-rich lung adenocarcinomas (ADCs), namely mucinous and colloid ADCs, are classified as ADC variants according to the World Health Organization 2015 classification. A correlation between morphological patterns mutational status of these rare entities is not well established. Methods We investigated profile mucin-rich ADCs in with histopathological features goal identifying biological tumor characteristics potential prognostic therapeutic interest. series 54 surgically resected primary samples were retrospectively analyzed for clinicopathological by targeted next-generation sequencing. Results Fifty cases invasive (32 pure 18 mixed) four colloid-predominant ADCs. Invasive a pattern associated lower risk vascular invasion ( p  = 0.01), absence signet ring cells 0.03), negative nodal 0.006), early clinical stage 0.02). The most prevalent mutations involved Kirsten rat sarcoma viral oncogene homolog gene KRAS ) protein p53 TP53 ). Most clustered mitogen-activated protein/protein kinase B pathway p53/DNA repair pathway. few uncommon epidermal growth factor receptor EGFR found. higher number favorable outcome was seen Conclusions Our data showed that have peculiar pathological molecular might suggest need differentially tailored approach compared conventional ADC.