MUC5AC and MUC5B enhance the characterization of mucinous adenocarcinomas of the lung and predict poor prognosis
作者： Young K Kim , Dong H Shin , Kyung B Kim , Nari Shin , Won Y Park
DOI: 10.1111/HIS.12693
关键词:
摘要: Aims From the viewpoint of histogenesis, lung adenocarcinoma can be subdivided into two groups: terminal respiratory unit (TRU) and non-TRU types. We recently reported a type designated as ciliated (we now prefer central adenocarcinoma). suggest reasons that mucinous should encompass to represent its biological characteristics adenocarcinoma. Methods results Mucin (MUC)5AC MUC5B were expressed more significantly in (P < 0.01). Thirty-five (76.1%) 45 cases (97.8%) 46 showed positivity for MUC5AC MUC5B. Twelve (7.6%) eight (5.1%) 157 TRU adenocarainoma MUC5AC. NKX2-1 gene expression was measured with quantitative reverse transcription–polymerase chain reaction (qRT–PCR). ΔΔCt 6.79 0.6 adenocarcinoma. Overall survival disease-free poorer (P = 0.02 P = 0.03). A multivariate test also is an independent prognostic factor (P = 0.04). Conclusion MUC5AC specific makers adenocarcinoma, including both presents prognosis, so it regarded separately from
sci-hub.se 参考文章(18)
Claes WICKSTRÖM, Julia R. DAVIES, Gitte V. ERIKSEN, Enno C. I. VEERMAN, Ingemar CARLSTEDT, MUC5B is a major gel-forming, oligomeric mucin from human salivary gland, respiratory tract and endocervix: identification of glycoforms and C-terminal cleavage. Biochemical Journal. ,vol. 334, pp. 685- 693 ,(1998) , 10.1042/BJ3340685
Mary Callaghan Rose, Judith A. Voynow, Respiratory Tract Mucin Genes and Mucin Glycoproteins in Health and Disease Physiological Reviews. ,vol. 86, pp. 245- 278 ,(2006) , 10.1152/PHYSREV.00010.2005
Gang Chen, Thomas R. Korfhagen, Yan Xu, Joseph Kitzmiller, Susan E. Wert, Yutaka Maeda, Alexander Gregorieff, Hans Clevers, Jeffrey A. Whitsett, SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production Journal of Clinical Investigation. ,vol. 119, pp. 2914- 2924 ,(2009) , 10.1172/JCI39731
Shizuki Tsukashita, Ryoji Kushima, Masamichi Bamba, Hiroyuki Sugihara, Takanori Hattori, MUC gene expression and histogenesis of adenocarcinoma of the stomach. International Journal of Cancer. ,vol. 94, pp. 166- 170 ,(2001) , 10.1002/IJC.1460
Yin Chen, Yu Hua Zhao, Yuan-Pu Di, Reen Wu, None, Characterization of human mucin 5B gene expression in airway epithelium and the genomic clone of the amino-terminal and 5'-flanking region. American Journal of Respiratory Cell and Molecular Biology. ,vol. 25, pp. 542- 553 ,(2001) , 10.1165/AJRCMB.25.5.4298
Won Young Park, Mi Hyun Kim, Dong Hoon Shin, Jung Hee Lee, Kyung Un Choi, Jee Yeon Kim, Do Youn Park, Chang Hun Lee, Mee Young Sol, Ciliated adenocarcinomas of the lung: a tumor of non-terminal respiratory unit origin Modern Pathology. ,vol. 25, pp. 1265- 1274 ,(2012) , 10.1038/MODPATHOL.2012.76
Chong-Jen Yu, Pan-Chyr Yang, Chia-Tung Shun, Yung-Chie Lee, Sow-Hsong Kuo, Kwen-Tay Luh, Overexpression of MUC5 genes is associated with early post-operative metastasis in non-small-cell lung cancer. International Journal of Cancer. ,vol. 69, pp. 457- 465 ,(1996) , 10.1002/(SICI)1097-0215(19961220)69:6<457::AID-IJC7>3.0.CO;2-3
William D Travis, Elisabeth Brambilla, Masayuki Noguchi, Andrew G Nicholson, Kim R Geisinger, Yasushi Yatabe, David G Beer, Charles A Powell, Gregory J Riely, Paul E Van Schil, Kavita Garg, John HM Austin, Hisao Asamura, Valerie W Rusch, Fred R Hirsch, Giorgio Scagliotti, Tetsuya Mitsudomi, Rudolf M Huber, Yuichi Ishikawa, James Jett, Montserrat Sanchez-Cespedes, Jean-Paul Sculier, Takashi Takahashi, Masahiro Tsuboi, Johan Vansteenkiste, Ignacio Wistuba, Pan-Chyr Yang, Denise Aberle, Christian Brambilla, Douglas Flieder, Wilbur Franklin, Adi Gazdar, Michael Gould, Philip Hasleton, Douglas Henderson, Bruce Johnson, David Johnson, Keith Kerr, Keiko Kuriyama, Jin Soo Lee, Vincent A Miller, Iver Petersen, Victor Roggli, Rafael Rosell, Nagahiro Saijo, Erik Thunnissen, Ming Tsao, David Yankelewitz, None, International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of Lung Adenocarcinoma Journal of Thoracic Oncology. ,vol. 6, pp. 244- 285 ,(2011) , 10.1097/JTO.0B013E318206A221
S Perner, PL Wagner, A Soltermann, C LaFargue, V Tischler, BA Weir, W Weder, M Meyerson, TJ Giordano, H Moch, MA Rubin, TTF1 expression in non-small cell lung carcinoma: association with TTF1 gene amplification and improved survival. The Journal of Pathology. ,vol. 217, pp. 65- 72 ,(2009) , 10.1002/PATH.2443
Eric L. Snyder, Hideo Watanabe, Margaret Magendantz, Sebastian Hoersch, Tiffany A. Chen, Diana G. Wang, Denise Crowley, Charles A. Whittaker, Matthew Meyerson, Shioko Kimura, Tyler Jacks, Nkx2-1 Represses a Latent Gastric Differentiation Program in Lung Adenocarcinoma Molecular Cell. ,vol. 50, pp. 185- 199 ,(2013) , 10.1016/J.MOLCEL.2013.02.018