Mortality and causes of death in patients with hemophilia, 1992-2001: a prospective cohort study.

摘要: Summary. Background: Clotting factor products have been safe for HIV since 1985, and hepatitis C 1992. Few studies reported on mortality in the total population of hemophilia patients after period risk viral infection transmission. Objectives: We studied mortality, causes death, life expectancy between 1992 2001. compared these findings with those previous cohorts, together spanning periods before, during, use potentially contaminated clotting products. Patients methods: performed a prospective cohort study among 967 A B. Death rates, overall cause-specific, were national figures males adjusted age calendar as standardized ratio (SMRs). Results: Between 2001, 94 (9.7%) had died two lost to follow-up (0.2%). Mortality was 2.3-times higher than general male (SMR 2.3 95% confidence interval 1.9–2.8). In severe hemophilia, decreased from 63 (1972–1985) 59 years (1992–2001). Exclusion virus-related deaths resulted at birth 72 years. Conclusions: AIDS main cause death (26%) 22% because C. not affected by infections, there still appeared be trend toward moderately increased Dutch population. Thus, is increased; this largely consequences infections.