Can antibodies with specificity for soluble antigens mimic the therapeutic effects of intravenous IgG in the treatment of autoimmune disease

摘要: Intravenous Ig (IVIg) mediates protection from the effects of immune thrombocytopenic purpura (ITP) as well numerous other autoimmune states; however, active antibodies within IVIg are unknown. There is some evidence that specific for a cell-associated antigen on erythrocytes responsible, at least in part, therapeutic effect ITP. Yet whether an directed to soluble can likewise be beneficial ITP or diseases also A murine model was used determine effectiveness IgG antigens treating purpura. Mice experimentally treated with OVA + anti-OVA versus mice conjugated rbcs (OVA-rbcs) were compared. In both situations, protected Both these experimental regimes acted complement-independent fashion and blocked reticuloendothelial function. contrast OVA-rbcs anti-OVA, (as IVIg) did not have any thrombocytopenia lacking inhibitory receptor FcgammaRIIB (FcgammaRIIB(-/-) mice). Similarly, reactive endogenous albumin transferrin ameliorated FcgammaRIIB-dependent manner. Finally, broadening significance experiments finding anti-albumin protective K/BxN serum-induced arthritis model. We conclude 2 disparate IVIg-treatable diseases.