Evaluation of subchronic inhalation toxicity of methylcyclopentane in rats.
作者： Young-Su Yang , Sung-Bae Lee , Seong-Jin Choi , Byoung-Seok Lee , Jeong-Doo Heo
DOI: 10.1016/J.FCT.2013.11.001
关键词:
摘要: Abstract The aim of this study was to verify subchronic inhalation toxicity methylcyclopentane (CAS No. 96-37-7) in Sprague-Dawley rats. Four groups 10 rats each gender were exposed vapor by whole-body at concentrations 0, 290, 1300, or 5870 ppm for 6 h per day, 5 days/week over a 13-week period. During the period, clinical signs, mortality, body weight, food consumption, ophthalmoscopy, urinalysis, hematology, serum biochemistry, gross pathology, organ weights, and histopathology examined. Exposure-related signs (salivation rubbing) observed both genders group. There an increase liver weight but kidney only higher females than controls. However, no toxicologically significant changes necropsy findings, any treatment groups. Under present experimental conditions, target organs determined be no-observed-adverse-effect concentration considered 1300 ppm/6 h/day
sci-hub.se 参考文章(36)
Yasuhiro TAKEUCHI, Naomi HISANAGA, Yuichiro ONO, Toshi INOUE, n-ヘキサンの毒性と量・反応関係 Japanese journal of industrial health. ,vol. 22, pp. 470- 487 ,(1980) , 10.1539/JOH1959.22.470
Charles G. Plopper, Roger A. Renne, Jeffrey I. Everitt, ToxPath Consulting, Roger Renne, Jack R. Harkema, Draft OECD Guidance Document on Histopathology for inhalation toxicity studies, Supporting TG 412 (Subacute Inhalation Toxicity: 28-Day) and TG 413 (Subchronic Inhalation Toxicity: 90-Day) ,(2009)
[edited by] Wanda M. Haschek, Colin G. Rousseaux, Fundamentals of Toxicologic Pathology ,(1997)
One‐Way Classifications John Wiley & Sons, Inc.. pp. 28- 70 ,(2005) , 10.1002/0471722073.CH2
Chin-Chang Huang, Polyneuropathy induced by n-hexane intoxication in Taiwan. Acta neurologica Taiwanica. ,vol. 17, pp. 3- 10 ,(2008) , 10.29819/ANT.200803.0001
M. S. Bartlett, Properties of Sufficiency and Statistical Tests Proceedings of The Royal Society A: Mathematical, Physical and Engineering Sciences. ,vol. 160, pp. 268- 282 ,(1992) , 10.1007/978-1-4612-0919-5_8
F. L. CAVENDER, H. W. CASEY, H. SALEM, D. G. GRAHAM, J. A. SWENBERG, E. J. GRALLA, A 13-week vapor inhalation study of n-hexane in rats with emphasis on neurotoxic effects. Toxicological Sciences. ,vol. 4, pp. 191- 201 ,(1984) , 10.1093/TOXSCI/4.2PART1.191
J.N. Lawrence, S. Starkey, F.M. Dickson, D.J. Benford, Use of human and rat keratinocyte cultures to assess skin irritation potential. Toxicology in Vitro. ,vol. 10, pp. 331- 340 ,(1996) , 10.1016/0887-2333(96)00005-7
Robert Tardif, Véronique Nadeau, Ginette Truchon, Martin Brochu, Effect of Physical Exertion on the Biological Monitoring of Exposure to Various Solvents Following Exposure by Inhalation in Human Volunteers: II. n-Hexane Journal of Occupational and Environmental Hygiene. ,vol. 3, pp. 481- 489 ,(2006) , 10.1080/15459620701401936
J-C Kim, D-H Shin, T-H Ahn, S-S Kang, S-W Song, J Han, C-Y Kim, C-S Ha, M-K Chung, 26-Week repeated oral dose toxicity study of the new quinolone antibacterial DW-116 in Sprague-Dawley rats. Food and Chemical Toxicology. ,vol. 41, pp. 637- 645 ,(2003) , 10.1016/S0278-6915(02)00325-3