Nature of airway inflammation and remodeling in chronic cough

摘要: Background Chronic cough may be a result of asthma and nonasthma causes, but it is unclear whether there are specific inflammatory or remodeling changes. Objective We determined airway mucosal changes in patients presenting with asthmatic associated nonasthmatic causes. Methods Patients chronic (n=33; postnasal drip/rhinitis 6, gastroesophageal reflux 5, bronchiectasis 3, idiopathic 19) (n=14) causes 15 healthy controls underwent fiberoptic bronchoscopy. Morphometry bronchial biopsies capsaicin sensitivity were assessed. Results Compared controls, submucosal eosinophils neutrophils increased ( P =.01). Subbasement membrane thickness, goblet cell area, vascularity, vessel size also both groups. Smooth muscle area was higher only =.0007 vs control =.019 cough). None the pathologic related to duration coughing. Cough heightened compared cough. The degree hyperplasia epithelial shedding positively correlated r =0.43; =.01; =0.40; =.02, respectively). Conclusion Features wall prominent airways as well These linked rather than asthma. Mast eosinophilia distinctive for