Effects of MEK on kinetics of n-hexane metabolites in serum.
作者： Eiji Shibata , Jian Huang , Naomi Hisanaga , Yuichiro Ono , Isao Saito
DOI: 10.1007/BF02010732
关键词:
摘要: The neurotoxicity ofn-hexane is thought to be caused ultimately by 2,5-hexanedione (2,5-HD), one of then-hexane metabolites. potentiation co-exposure with MEK, therefore, suspected related kinetics 2,5-HD in blood. To clarify the metabolites mixed exposure and rats were exposed 2000 ppmn-hexane or a mixture ppm time courses serumn-hexane determined. serum increased until 2 h after end exposure, when concentration reached peak 16.35 μg/ml then-hexane-alone group. In contrast, group much more slowly during than It 2.12 at 8 exposure. Serum MBK, precursor group, was about half However, MBK decreased results suggest that co-exposed MEK might inhibit oxidation decrease clearance Co-exposed did not increase 2,5-HD, which considered main neurotoxic metabolite. Therefore enhancement could attributed mechanism should studied further.
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Masamitsu Iwata, Yasuhiro Takeuchi, Naomi Hisanaga, Yuichiro Ono, Changes of n-hexane neurotoxicity and its urinary metabolites by long-term co-exposure with MEK or toluene. International Archives of Occupational and Environmental Health. ,vol. 54, pp. 273- 281 ,(1984) , 10.1007/BF00378580
W RALSTON, Potentiation of 2,5-hexanedione neurotoxicity by methyl ethyl ketone*1, *2 Toxicology and Applied Pharmacology. ,vol. 81, pp. 319- 327 ,(1985) , 10.1016/0041-008X(85)90169-3
Y Takeuchi, Y Ono, N Hisanaga, M Iwata, M Aoyama, J Kitoh, Y Sugiura, An experimental study of the combined effects of n-hexane and methyl ethyl ketone. Occupational and Environmental Medicine. ,vol. 40, pp. 199- 203 ,(1983) , 10.1136/OEM.40.2.199
D COURI, The influence of inhaled ketone solvent vapors on hepatic microsomal biotransformation activities*1 Toxicology and Applied Pharmacology. ,vol. 41, pp. 285- 289 ,(1977) , 10.1016/0041-008X(77)90029-1
H. Altenkirch, G. Stoltenburg, H. M. Wagner, Experimental studies on hydrocarbon neuropathies induced by methyl-ethyl-ketone (MEK). Journal of Neurology. ,vol. 219, pp. 159- 170 ,(1978) , 10.1007/BF00314531
M. S. ABDEL-RAHMAN, L. B. HETLAND, D. COURI, Toxicity and metabolism of methyl n-butyl ketone American Industrial Hygiene Association Journal. ,vol. 37, pp. 95- 102 ,(1976) , 10.1080/0002889768507418
L. Perbellini, F. Brugnone, I. Pavan, Identification of the metabolites of n-hexane, cyclohexane, and their isomers in men's urine Toxicology and Applied Pharmacology. ,vol. 53, pp. 220- 229 ,(1980) , 10.1016/0041-008X(80)90422-6
N. Fedtke, H. M. Bolt, The relevance of 4,5-dihydroxy-2-hexanone in the excretion kinetics of n-hexane metabolites in rat and man. Archives of Toxicology. ,vol. 61, pp. 131- 137 ,(1987) , 10.1007/BF00661371
Masamitsu Iwata, Yasuhiro Takeuchi, Naomi Hisanaga, Yuichiro Ono, Changes of n-hexane metabolites in urine of rats exposed to various concentrations of n-hexane and to its mixture with toluene or MEK. International Archives of Occupational and Environmental Health. ,vol. 53, pp. 1- 8 ,(1983) , 10.1007/BF00406172
E. Shibata, J. Huang, Y. Ono, N. Hisanaga, M. Iwata, I. Saito, Y. Takeuchi, Changes in urinary n-hexane metabolites by co-exposure to various concentrations of methyl ethyl ketone and fixed n-hexane levels. Archives of Toxicology. ,vol. 64, pp. 165- 168 ,(1990) , 10.1007/BF01974405