Intestinal amoebiasis: 160 years of its first detection and still remains as a health problem in developing countries.

摘要: Amoebiasis is a parasitic disease caused by Entamoeba histolytica (E. histolytica), an extracellular enteric protozoan. This infection mainly affects people from developing countries with limited hygiene conditions, where it endemic. Infective cysts are transmitted the fecal-oral route, excysting in terminal ileum and producing invasive trophozoites (amoebae). E. lives large intestine without causing symptoms; however, possibly as result of so far unknown signals, amoebae invade mucosa epithelium intestinal amoebiasis. possesses different mechanisms pathogenicity for adherence to degrading matrix proteins, tissue lesions that progress abscesses host acute inflammatory response. Much information has been obtained regarding virulence factors, metabolism, pathogenicity, immune response against this parasite; addition, alternative treatments metronidazole continually emerging. An accesible low-cost diagnostic method can distinguish most nonpathogenic effective vaccine necessary protecting However, research about its prevention challenge due relationship between during distinct stages multifaceted. In review, we analyze interaction parasite, human host, colon microbiota or pathogenic microorganisms, which together give rise