Results From a Prospective, International, Epidemiologic Study of Invasive Candidiasis in Children and Neonates

摘要: BACKGROUND:: Candida species are the third most common cause of pediatric healthcareassociated bloodstream infection in United States and Europe. To our knowledge, this report from International Pediatric Fungal Network is largest prospective, multi-center observational study dedicated to neonatal invasive candidiasis. METHODS:: From 2007-2011, we enrolled 196 25 patients with RESULTS:: Non-albicans predominated (56%) (52%) age groups, yet C. albicans was both groups. Successful treatment responses were observed (76%) (92%). Infection parapsilosis led successful (92%) (100%) patients, while glabrata associated a lower outcome (55%). The commonly used primary antifungal therapies for candidiasis fluconazole (21%), liposomal amphotericin B (20%), micafungin (18%). Outcome similar response polyenes (73%), triazoles (67%) echinocandins (73%). (32%), caspofungin (24%), (16%) (8%). Outcomes by class again revealed rates amongst classes. CONCLUSIONS:: We found predominance non-albicans children outcomes based on used. This international collaborative sets foundation large epidemiologic studies focusing unique features comparative therapeutic interventions these populations.