High serum levels of soluble Fas (sFas) in CKD patients: effects of renal clearance, reabsorption and synthesis.
作者： M. A. Dalboni , M. A. Cenedeze , S. R. Manfredi , M. C. Cruz Andreoli , O. Paväo Dos Santos
DOI: 10.1177/039139880803100505
关键词:
摘要: PURPOSE Increased serum concentrations of soluble Fas (sFas) have been reported in patients with chronic kidney disease (CKD). However, little is known about the renal clearance sFas, whether sFas reabsorbed tubules, or behavior synthesis CKD. MATERIALS AND METHODS We studied 69 CKD (60+/-15 years old, creatinine 37+19 ml/min/1.73 m2) and 14 healthy subjects (61+/-17 years, 79+/-24 m2). ELISA was used to measure levels (pg/mL) retinol binding protein (RBP - mg/L). RT-PCR quantify sFasmRNA leukocytes. RESULTS Serum were significantly higher (2781+/-1214 vs. 2196+/-773, p=0.02). The 24-hour urine samples (23+/-27 40+/-17, p=0.006) Clearance (0.019+/-0.022 0.036+/-0.020, p=0.01) lower correlated (r=0.25, Urine RBP (r=0.80, p<0.001). (3.9+/-1.8 2.5+/-0.9, CONCLUSIONS In patients, decrease function followed by a an increase sFas. proximal tubule dysfunction (high urinary concentrations), also increased, suggesting that tubule. It possible contributes uremia.
sci-hub.se 参考文章(24)
G Papoff, G Ruberti, I Cascino, G Fiucci, Three functional soluble forms of the human apoptosis-inducing Fas molecule are produced by alternative splicing. Journal of Immunology. ,vol. 154, pp. 2706- 2713 ,(1995)
Maciej Szymański, Jan Barciszewski, Regulation by RNA. International Review of Cytology-a Survey of Cell Biology. ,vol. 231, pp. 197- 258 ,(2003) , 10.1016/S0074-7696(03)31005-8
Stamatis Adamopoulos, John T. Parissis, Michael Georgiadis, Dimitrios Karatzas, John Paraskevaidis, Christos Kroupis, George Karavolias, Katerina Koniavitou, Dimitrios Th. Kremastinos, Growth hormone administration reduces circulating proinflammatory cytokines and soluble Fas/soluble Fas ligand system in patients with chronic heart failure secondary to idiopathic dilated cardiomyopathy American Heart Journal. ,vol. 144, pp. 359- 364 ,(2002) , 10.1067/MHJ.2002.124052
Kazuhiko Nishigaki, Shinya Minatoguchi, Mitsuru Seishima, Kiyoji Asano, Toshiyuki Noda, Norio Yasuda, Hirotake Sano, Hirokazu Kumada, Masao Takemura, Akio Noma, Tsutomu Tanaka, Sachiro Watanabe, Hisayoshi Fujiwara, Plasma Fas ligand, an inducer of apoptosis, and plasma soluble Fas, an inhibitor of apoptosis, in patients with chronic congestive heart failure Journal of the American College of Cardiology. ,vol. 29, pp. 1214- 1220 ,(1997) , 10.1016/S0735-1097(97)00055-7
J Cheng, T Zhou, C Liu, J. Shapiro, M. Brauer, M. Kiefer, P. Barr, J. Mountz, Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule Science. ,vol. 263, pp. 1759- 1762 ,(1994) , 10.1126/SCIENCE.7510905
V. Gavrilov, T. Yermiahu, R. Gorodischer, Renal pathology and retinol status in multiple myeloma patients. Kidney International. ,vol. 69, pp. 173- 177 ,(2006) , 10.1038/SJ.KI.5000024
Maria Aparecida Dalboni, Camila Sardenberg, Maria Claudia Andreoli, Renato Watanabe, Maria Eugenia Canziani, Bento F.C. dos Santos, Orfeas Liangos, Bertrand L. Jaber, Sergio Draibe, Miguel Cendoroglo, Soluble Fas: A Novel Marker of Inflammation in Uremia Artificial Organs. ,vol. 27, pp. 687- 691 ,(2003) , 10.1046/J.1525-1594.2003.07274.X
Tomoaki Ohtsuka, Mareomi Hamada, Osamu Sasaki, Makoto Suzuki, Yuji Hara, Yuji Shigematsu, Takashi Ohtani, Toshio Honda, Kunio Hiwada, CLINICAL IMPLICATIONS OF CIRCULATING SOLUBLE FAS AND FAS LIGAND IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION Coronary Artery Disease. ,vol. 10, pp. 221- 226 ,(1999) , 10.1097/00019501-199906000-00003
B Hosaka, S.I Park, C.R Felipe, R.G Garcia, P.G.P Machado, A.B Pereira, H Tedesco-Silva, J.O Medina-Pestana, Predictive value of urinary retinol binding protein for graft dysfunction after kidney transplantation Transplantation Proceedings. ,vol. 35, pp. 1341- 1343 ,(2003) , 10.1016/S0041-1345(03)00380-4
Mary C. Perianayagam, Sandra L. Murray, V.S. Balakrishnan, Daqing Guo, Andrew J. King, Brian J.G. Pereira, Bertrand L. Jaber, Serum soluble Fas (CD95) and Fas ligand profiles in chronic kidney failure. Journal of Laboratory and Clinical Medicine. ,vol. 136, pp. 320- 327 ,(2000) , 10.1067/MLC.2000.109318