Interpreting biomarker data from the COPHES/DEMOCOPHES twin projects: Using external exposure data to understand biomarker differences among countries.

摘要: In 2011 and 2012, the COPHES/DEMOCOPHES twin projects performed first ever harmonized human biomonitoring survey in 17 European countries. more than 1800 mother-child pairs, individual lifestyle data were collected cadmium, cotinine certain phthalate metabolites measured urine. Total mercury was determined hair samples. While main goal of to develop test protocols procedures, current paper is investigate whether observed differences biomarker values among countries implementing DEMOCOPHES can be interpreted using information from external databases on environmental quality lifestyle. general, 13 having implemented provided high-quality sources that relevant for interpretation purposes. However, some not available reporting or line with predefined specifications. Therefore, only part could included statistical analyses. Nonetheless, there a highly significant correlation between national levels fish consumption hair, strength antismoking legislation significantly related urinary levels, we able show indications also cadmium associated food quality. These results again potential provide added value (the evaluation of) evidence-informed policy making.