Bromobenzene and p-bromophenol toxicity and covalent binding
作者： Terrence J. Monks , Jack A. Hinson , James R. Gillette
DOI: 10.1016/0024-3205(82)90598-7
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摘要: Abstract A hepatotoxic dose of bromobenzene (3 mmoles/kg) decreases hepatic glutathione concentration in rats by approximately 80% within 5 hr following ip injection. major metabolite, p-bromophenol at a similar did not significantly alter levels compared to controls. Twenty four after administration, serum glutamate pyruvate transaminase (SGPT) were increased but p-bromophenol. After 14C-bromobenzene significant amount covalently bound radiolabel was detected liver, kidney and small intestine. also the lung. 14C-bromophenol, found liver (62% with 14C-bromobenzene) smaller amounts kidney, intestine These data are consistent view that hepatotoxity depleting ability mediated mainly bromobenzene-3, 4-oxide rather than chemically reactive metabolites derived from bromobenzene. Covalently 14C-bromobenzene, however, may be both nontoxic
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sci-hub.se 参考文章(18)
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
Sigrun Hesse, Margot Mezger, Thomas Wolff, Activation of [14C] chlorobiphenyls to protein-binding metabolites by rat liver microsomes. Chemico-Biological Interactions. ,vol. 20, pp. 355- 365 ,(1978) , 10.1016/0009-2797(78)90113-8
W.D. Reid, B. Christie, G. Krishna, J.R. Mitchell, J. Moskowitz, B.B. Brodie, Bromobenzene metabolism and hepatic necrosis. Pharmacology. ,vol. 6, pp. 41- 55 ,(1971) , 10.1159/000136226
James R. Gillette, A perspective on the role of chemically reactive metabolites of foreign compounds in toxicity. II. Alterations in the kinetics of covalent binding. Biochemical Pharmacology. ,vol. 23, pp. 2927- 2938 ,(1974) , 10.1016/0006-2952(74)90267-6
Watson D. Reid, Basil Christie, Michel Eichelbaum, Gopal Krishna, 3-methylcholanthrene blocks hepatic necrosis induced by administration of bromobenzene or carbon tetrachloride Experimental and Molecular Pathology. ,vol. 15, pp. 363- 372 ,(1971) , 10.1016/0014-4800(71)90043-8
Watson D. Rein, Gopal Krishna, Centrolobular hepatic necrosis related to covalent binding of metabolites of halogenated aromatic hydrocarbons. Experimental and Molecular Pathology. ,vol. 18, pp. 80- 99 ,(1973) , 10.1016/0014-4800(73)90009-9
James R. Gillette, A perspective on the role of chemically reactive metabolites of foreign compounds in toxicity—I correlation of changes in covalent binding of reactivity metabolites with changes in the incidence and severity of toxicity Biochemical Pharmacology. ,vol. 23, pp. 2785- 2794 ,(1974) , 10.1016/0006-2952(74)90052-5
William F. Greenlee, James D. Sun, James S. Bus, A proposed mechanism of benzene toxicity: Formation of reactive intermediates from polyphenol metabolites Toxicology and Applied Pharmacology. ,vol. 59, pp. 187- 195 ,(1981) , 10.1016/0041-008X(81)90189-7
I.M. Reid, An ultrastructural and morphometric study of the liver of the lactating cow in starvation ketosis. Experimental and Molecular Pathology. ,vol. 18, pp. 316- 330 ,(1973) , 10.1016/0014-4800(73)90028-2
D.J. Jollow, J.R. Mitchell, N. Zampaglione, J.R. Gillette, Bromobenzene-Induced Liver Necrosis. Protective Role of Glutathione and Evidence for 3,4-Bromobenzene Oxide as the Hepatotoxic Metabolite Pharmacology. ,vol. 11, pp. 151- 169 ,(1974) , 10.1159/000136485