Chemically induced nephrotoxicity: role of metabolic activation.
作者： Glenn F. Rush , Jacqueline H. Smith , John F. Newton , Jerry B. Hook , William O. Berndt
DOI: 10.3109/10408448409034079
关键词: Xenobiotic 、 Cysteine lyase 、 Kidney 、 Nephrotoxicity 、 Glutathione 、 Biochemistry 、 Chemistry 、 Drug metabolism 、 Cytochrome P450 、 Lipid peroxidation
摘要: Renal xenobiotic metabolism can result in production of electrophiles or free radicals that may covalently bind macromolecules initiate lipid peroxidation. The mechanisms renal vary different anatomical regions. Kidney cortex contains a cytochrome P-450 system while medulla prostaglandin endoperoxidase. Recently cysteine conjugated-lyase has been implicated reactive intermediates. Metabolic activation be amplified by accumulation xenobiotics within cells due to tubular concentrating and/or secretory mechanisms. Additionally, detoxicification occur conjugation with glucuronide, sulfate glutathione.
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