Long Non-coding RNA in Neurons: New Players in Early Response to BDNF Stimulation.

摘要: Brain-derived neurotrophic factor (BDNF) is a neurotrophin family member that highly expressed and widely distributed in the brain. BDNF critical for neural survival plasticity both during development adulthood, dysfunction its signaling may contribute to number of neurodegenerative disorders. Deep understanding BDNF-activated molecular cascade thus help find new biomarkers therapeutic targets. One interesting direction related early phase BDNF-dependent gene expression regulation, which responsible activation selective programs lead stable functional structural remodeling neurons. Immediate-early coding genes activated by are under investigation, but involvement non-coding RNAs largely unexplored, especially long (lncRNAs). lncRNAs emerging as key regulators can orchestrate different aspects nervous system development, homeostasis, plasticity, making them attractive candidate markers targets brain diseases. We used microarray technology identify differentially immediate response stimulation neuronal cell model. Our observations on putative role provide clues their master triggered BDNF.