Serum anti-GAGA4 IgM antibodies differentiate relapsing remitting and secondary progressive multiple sclerosis from primary progressive multiple sclerosis and other neurological diseases.
作者： Johannes Brettschneider , Troy D. Jaskowski , Hayrettin Tumani , Sana Abdul , Dee Husebye
DOI: 10.1016/J.JNEUROIM.2009.07.017
关键词:
摘要: Abstract The serum level of IgM antibodies against Glc(α1,4)Glc(α) (GAGA4) is higher in relapsing remitting multiple sclerosis (RRMS) compared to other neurological disease (OND) patients and healthy controls (HC). Detecting the anti-GAGA4 antibody by enzyme immunoassay total IgM, we confirmed that can differentiate RRMS from OND HC. Moreover, secondary progressive MS (SPMS) have similar levels demonstrating biomarker's presence throughout disease. Interestingly, assay may also between primary (PPMS) RRMS/SPMS patients, since nearly all PPMS were negative for assay.
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Charles M. Poser, Donald W. Paty, Labe Scheinberg, W. Ian McDonald, Floyd A. Davis, George C. Ebers, Kenneth P. Johnson, William A. Sibley, Donald H. Silberberg, Wallace W. Tourtellotte, New diagnostic criteria for multiple sclerosis: Guidelines for research protocols Annals of Neurology. ,vol. 13, pp. 227- 231 ,(1983) , 10.1002/ANA.410130302
L. K. Fisniku, P. A. Brex, D. R. Altmann, K. A. Miszkiel, C. E. Benton, R. Lanyon, A. J. Thompson, D. H. Miller, Disability and T2 MRI lesions: a 20-year follow-up of patients with relapse onset of multiple sclerosis. Brain. ,vol. 131, pp. 808- 817 ,(2008) , 10.1093/BRAIN/AWM329
Vanda A. Lennon, Thomas J. Kryzer, Sean J. Pittock, A.S. Verkman, Shannon R. Hinson, IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel Journal of Experimental Medicine. ,vol. 202, pp. 473- 477 ,(2005) , 10.1084/JEM.20050304
P. Patrikios, C. Stadelmann, A. Kutzelnigg, H. Rauschka, M. Schmidbauer, H. Laursen, P. S. Sorensen, W. Bruck, C. Lucchinetti, H. Lassmann, Remyelination is extensive in a subset of multiple sclerosis patients Brain. ,vol. 129, pp. 3165- 3172 ,(2006) , 10.1093/BRAIN/AWL217
KM Brousseau, DB Arciniegas, MJ Carmosino, JR Corboy, The differential diagnosis of Axis I psychopathology presenting to a university-based multiple sclerosis clinic: Multiple Sclerosis Journal. ,vol. 13, pp. 749- 753 ,(2007) , 10.1177/1352458506075032
C. Lucchinetti, Pathological Heterogeneity of Idiopathic Central Nervous System Inflammatory Demyelinating Disorders Current Topics in Microbiology and Immunology. ,vol. 318, pp. 19- 43 ,(2008) , 10.1007/978-3-540-73677-6_2
M Daumer, , A Neuhaus, C Lederer, M Scholz, JS Wolinsky, M Heiderhoff, Prognosis of the individual course of disease--steps in developing a decision support tool for Multiple Sclerosis. BMC Medical Informatics and Decision Making. ,vol. 7, pp. 11- 11 ,(2007) , 10.1186/1472-6947-7-11
Anne I. Boullerne, José J. Rodrı́guez, Tarik Touil, Bruno Brochet, Stephan Schmidt, Nora D. Abrous, Michel Le Moal, Jeffrey R. Pua, Mark A. Jensen, Willy Mayo, Barry G. W. Arnason, Klaus G. Petry, Anti-S-nitrosocysteine antibodies are a predictive marker for demyelination in experimental autoimmune encephalomyelitis: implications for multiple sclerosis. The Journal of Neuroscience. ,vol. 22, pp. 123- 132 ,(2002) , 10.1523/JNEUROSCI.22-01-00123.2002
David Miller, Frederik Barkhof, Xavier Montalban, Alan Thompson, Massimo Filippi, Clinically isolated syndromes suggestive of multiple sclerosis, part I: natural history, pathogenesis, diagnosis, and prognosis Lancet Neurology. ,vol. 4, pp. 281- 288 ,(2005) , 10.1016/S1474-4422(05)70071-5
Lawrence D Jacobs, Roy W Beck, Jack H Simon, R Phillip Kinkel, Carol M Brownscheidle, Thomas J Murray, Nancy A Simonian, Peter J Slasor, Alfred W Sandrock, CHAMPS Study Group, None, Intramuscular Interferon Beta-1A Therapy Initiated during a First Demyelinating Event in Multiple Sclerosis New England Journal of Medicine. ,vol. 343, pp. 898- 904 ,(2000) , 10.1056/NEJM200009283431301