摘要: Bone is the main component of skeleton, together with connecting tissues including cartilage, ligaments and tendons, providing mechanical structural support for remaining organs systems in body. This function indispensable life, both during growth development period as well adult life. However, bone also provides unique architecture microenvironment that preserve niches which maintain immature stem cells. niche aspect an inadequately recognized function, although essential one, since cells are required tissue repair regeneration In addition to support, contains supports reservoir needed sustain integrity throughout our lives. Thus, understanding how made maintained life central developing adequate strategies a healthy skeleton we age, so proper capacity maintained.