Cryo-EM as a powerful tool for drug discovery.
作者： John H Van Drie , Liang Tong
DOI: 10.1016/J.BMCL.2020.127524
关键词:
摘要: The recent revolution in cryo-EM has produced an explosion of structures at near-atomic or better resolution. This allowed to provide visualization bound small-molecule ligands the macromolecules, and these new have provided unprecedented insights into molecular mechanisms complex biochemical processes. They also had a profound impact on drug discovery, defining binding modes action well-known drugs as well driving design development compounds. review will summarize highlight some structures. Most excitingly, latest technology 1.2 A resolution, further solidifying powerful tool for discovery. Therefore, play ever-increasing role discovery coming years.
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