3D approaches to model the tumor microenvironment of pancreatic cancer.

摘要: In tumor engineering, 3D approaches are used to model components of the microenvironment and test new treatments. Pancreatic cancers a cancer substantial unmet need survival rates lower compared any other cancer. Bioengineering techniques increasingly applied understand unique biology pancreatic tumors design patient-specific models. Here we summarize how extracellular cellular elements their interactions have been studied in cell cultures. We review selected clinical trials, assess benefits therapies interfering with address limitations future perspectives.