Bone marrow mast cell burden and serum tryptase level as markers of response in patients with systemic mastocytosis
作者： Alfonso Quintás-Cardama , Matjaz Sever , Jorge Cortes , Hagop Kantarjian , Srdan Verstovsek
DOI: 10.3109/10428194.2012.763121
关键词:
摘要: AbstractTwo important response criteria in systemic mastocytosis (SM) are the elimination or reduction percentage of bone marrow mast cells (MCs) and serum tryptase levels. We investigated accuracy a single time point MCs level as 50 patients with SM available serial assessments. Bone MC varied significantly, an average coefficient variation (CV) 65% (range, 6–173%) 44% having CV higher than average. The for was 19% 0–96%), 36% These wide variations burden were independent administration SM-directed therapy, type therapy disease subtype. Furthermore, achievement therapy-induced complete (no histological evidence malignant MCs) did not correlate tr...
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