Development of a murine model of traumatic benign paroxysmal positional vertigo: a preliminary study
作者： Chan Joo Yang , Ji-Won Lee , Sung-Jin Kim , Chang-Whan Lee , Hong Ju Park
DOI: 10.1080/00016489.2016.1217043
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摘要: AbstractConclusion: The results showed a gradual detachment of otoconia in the utricle after single event head vibration, possibly explaining frequent recurrence BPPV attacks and persistent dizziness trauma.Objectives: This study developed murine model traumatic observed changes over time.Methods: Six-week-old CBA mice were used this study. Otoconia was induced by vibrating for 2 min. Utricles harvested from different groups: before vibration 1 day, 1 week, month, 3 months application. Using scanning electron microscopy ImageJ software, percentage intact area calculated. Hearing thresholds compared among groups.Results: mean (± SD) percentages 98.1% ± 1.7% 93.6% ± 1.7%, 88.9% ± 5.3%, 78.2% ± 20.9%, 38.9% ± 24.1% at an...
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