Multi-epitope based peptide vaccine design against SARS-CoV-2 using its spike protein

摘要: SARS CoV-2 has particularly been efficient in ensuring that entire countries are brought to a standstill. With repercussions ranging from rampant mortality, fear, paranoia and economic recession the virus together order look at possible therapeutic countermeasures. prophylactic interventions possibly months away being effective, slew of measures possibilities concerning design vaccines worked upon. We attempt structure based approach utilizing combination epitope prediction servers develop multi-epitope subunit vaccine involves two major domains spike glycoprotein ( S1 S2) coupled with substantially effective chimeric adjuvant acting as triagonist create stable constructs through MD simulations. The designed evaluated on their docking Toll Like Receptor (TLR) 4. Our findings provide epitope-based peptide fragment which can be potential candidates for development against SARS-CoV-2.