Impaired effectiveness of nitric oxide-donors in resistance arteries of patients with arterial hypertension.

摘要: Dilation of resistance arteries in response to infusion nitric oxide donors is impaired hypertensive patients and the degree this impairment depends critically on severity arterial hypertension. The reduced effectiveness appears be independent class donor thus mode intravascular generation. These findings are likely have important implications not only for our understanding pathophysiological mechanisms endothelial dysfunction but also therapy