Effect of CCK antibodies on food intake and weight gain in zucker rats

摘要: While exogenous administration of cholecystokinin (CCK) decreases food intake in many species, it has not been demonstrated conclusively that CCK is necessary for satiety to occur. In these experiments the role eliciting was further investigated by using endogenously produced and exogenously administered antibodies which were hypothesized sequester circulating CCK. first experiment Zucker obese (n = 12, 192 +/- 16 g) lean 152 11 male rats CCK-8 conjugated bovine serum albumin or subcutaneous Freund's adjuvant. Average percent binding 125I-gastrin-17 taken 4, 8 12 weeks after treatment initiation increased (19.9 vs. 2.1, p less than 0.001) treated with conjugate controls, increase greater (27.5 1.9) (12.2 2.2, rats. lean, but rats, average daily weight gain (9 17% 0.04 0.02 respectively) CCK-AB compared no during three months. Development did affect response pancreas relative body weight. Experiment 2 intakes 30 min intraperitoneal injection rabbit those without (1.92 1.41, g, 0.007).(ABSTRACT TRUNCATED AT 250 WORDS)