Cholecystokinin octapeptide: continuous picomole injections into the cerebral ventricles of sheep suppress feeding

摘要: Cholecystokinin octapeptide decreased food intake in a dose-related manner when injected continuously into the lateral cerebral ventricles of sheep that had been deprived for 2, 4, 8, or 24 hours. In 2 hours, as little 0.01 picomole per minute suppressed feeding 35 percent 1 hour after beginning injection. Pentagastrin also 2-hour group, but only at much higher dose range. Secretin no effect. These findings support hypothesis cholecystokinin acts on central nervous system structures are involved control intake.