Influence of Vehicle, Distant Topical Delivery, and Biotransformation on the Chemopreventive Activity of Apigenin, a Plant Flavonoid, in Mouse Skin

作者: Boyong Li , Heather Pinch , Diane R Birt

DOI: 10.1023/A:1016083613916

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摘要: Purpose. This study was designed to (a) establish a short-term in vivo system evaluate topical formulations of apigenin, (b) determine whether apigenin should be topically delivered the local skin tissue or systemic circulation, (c) investigate if biotransformation involved apigenin's chemopreventive activity.

参考文章(6)
Hackett Am, The metabolism of flavonoid compounds in mammals. Progress in Clinical and Biological Research. ,vol. 213, pp. 177- 194 ,(1986)
Diane F. Birt, Laura Tye, Huachen Wei, Edward Bresnick, Inhibitory effect of apigenin, a plant flavonoid, on epidermal ornithine decarboxylase and skin tumor promotion in mice. Cancer Research. ,vol. 50, pp. 499- 502 ,(1990)
S. Menicagli, P. Puccini, V. Longo, P.G. Gervasi, Effect of acetone administration on renal, pulmonary and hepatic monooxygenase activities in hamster. Toxicology. ,vol. 64, pp. 141- 153 ,(1990) , 10.1016/0300-483X(90)90131-Y