Atrophy of hippocampal subfields and adjacent extrahippocampal structures in dementia with Lewy bodies and Alzheimer's disease.
作者： Stefano Delli Pizzi , Raffaella Franciotti , Giovanna Bubbico , Astrid Thomas , Marco Onofrj
DOI: 10.1016/J.NEUROBIOLAGING.2016.01.010
关键词:
摘要: The hippocampus and adjacent extrahippocampal structures are organized in distinct specialized regions which process heterogeneous functions, including memory, visuospatial functions. Specific alterations of the different hippocampal subfields could differently contribute to pathophysiology Alzheimer's disease (AD) dementia with Lewy bodies (DLB). Based on visual symptoms characterize DLB patients, mainly involved functions be impaired preserved AD. To test this hypothesis, we performed structural magnetic resonance imaging 19 DLB, 15 AD, age-matched healthy controls. FreeSurfer's pipelines were used perform parcellation assess changes within each region. cornu ammonis subiculum bilaterally damaged AD DLB. perirhinal cortex parahippocampus but not Our findings demonstrate that altered Particularly, patients showed a more focused alteration linked
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