Supplementing vitamin B6 to a low vitamin B6 diet exaggerates UVB-induced skin tumorigenesis in DMBA-treated hairless mice.
作者： Tao LU , Yonghui XU , Elise Saiz MONTTINEN , Norihisa KATO
DOI: 10.3177/JNSV.54.262
关键词:
摘要: 7,12-Dimethylbenz[a]anthracene (DMBA)-treated hairless mice exposed to UVB radiation were used examine the effect of graded levels vitamin B6 [1, 7 or 35 mg pyridoxine (PN) HCl/kg] on skin tumorigenesis for 18 wk. Compared 1 PN HCl/kg diet, diet significantly elevated incidence and multiplicity tumors, while there was no difference in between diets. Skin oxidative stress markers (lipid peroxides protein carbonyls) unaffected by dietary treatment. diets serum pyridoxal 5'-phosphate (PLP) without affecting level PLP. The results suggest that supplemental exaggerates UVB-induced skin.
sci-hub.se 参考文章(24)
Kohkichi Morimoto, Akira Kawada, Masataro Hiruma, Akira Ishibashi, Photosensitivity from pyridoxine hydrochloride (vitamin B6) Journal of The American Academy of Dermatology. ,vol. 35, pp. 304- 305 ,(1996) , 10.1016/S0190-9622(96)90654-4
Stephen P. Coburn, A Critical Review of Minimal Vitamin B6 Requirements for Growth in Various Species with a Proposed Method of Calculation Vitamins and Hormones Series. ,vol. 48, pp. 259- 300 ,(1994) , 10.1016/S0083-6729(08)60500-2
Philip G. Reeves, Forrest H. Nielsen, George C. Fahey, AIN-93 Purified Diets for Laboratory Rodents: Final Report of the American Institute of Nutrition Ad Hoc Writing Committee on the Reformulation of the AIN-76A Rodent Diet Journal of Nutrition. ,vol. 123, pp. 1939- 1951 ,(1993) , 10.1093/JN/123.11.1939
Phyllis A. Cohen, Karmela Schneidman, Fredda Ginsberg-Fellner, John A. Sturman, Jerome Knittle, Gerald E. Gaull, High Pyridoxine Diet in the Rat: Possible Implications for Megavitamin Therapy The Journal of Nutrition. ,vol. 103, pp. 143- 151 ,(1973) , 10.1093/JN/103.1.143
Shun-ichiro KOMATSU, Hiromitsu WATANABE, Tatsuzo OKA, Haruhito TSUGE, Norihisa KATO, Dietary Vitamin B6 Suppresses Colon Tumorigenesis, 8-Hydroxyguanosine, 4-Hydroxynonenal, and Inducible Nitric Oxide Synthase Protein in Azoxymethane-Treated Mice Journal of Nutritional Science and Vitaminology. ,vol. 48, pp. 65- 68 ,(2002) , 10.3177/JNSV.48.65
Krishnaswamy Kannan, Sushil K Jain, Effect of vitamin B6 on oxygen radicals, mitochondrial membrane potential, and lipid peroxidation in H2O2-treated U937 monocytes. Free Radical Biology and Medicine. ,vol. 36, pp. 423- 428 ,(2004) , 10.1016/J.FREERADBIOMED.2003.09.012
Sushil K Jain, Gideon Lim, Pyridoxine and pyridoxamine inhibits superoxide radicals and prevents lipid peroxidation, protein glycosylation, and (Na+ + K+)-ATPase activity reduction in high glucose-treated human erythrocytes. Free Radical Biology and Medicine. ,vol. 30, pp. 232- 237 ,(2001) , 10.1016/S0891-5849(00)00462-7
Georg T. Wondrak, Michael J. Roberts, Myron K. Jacobson, Elaine L. Jacobson, 3-Hydroxypyridine Chromophores Are Endogenous Sensitizers of Photooxidative Stress in Human Skin Cells Journal of Biological Chemistry. ,vol. 279, pp. 30009- 30020 ,(2004) , 10.1074/JBC.M404379200
Noriyuki Yanaka, Taka-Aki Koyama, Shun-Ichiro Komatsu, Eri Nakamura, Mayumi Kanda, Norihisa Kato, Vitamin B6 suppresses NF-κB activation in LPS-stimulated mouse macrophages International Journal of Molecular Medicine. ,vol. 16, pp. 1071- 1075 ,(2005) , 10.3892/IJMM.16.6.1071
Haruhito Tsuge, DETERMINATION OF VITAMIN B6 VITAMERS AND METABOLITES IN A BIOLOGICAL SAMPLE Methods in Enzymology. ,vol. 280, pp. 3- 12 ,(1997) , 10.1016/S0076-6879(97)80095-X