Dietary Vitamin B6 Suppresses Colon Tumorigenesis, 8-Hydroxyguanosine, 4-Hydroxynonenal, and Inducible Nitric Oxide Synthase Protein in Azoxymethane-Treated Mice
作者： Shun-ichiro KOMATSU , Hiromitsu WATANABE , Tatsuzo OKA , Haruhito TSUGE , Norihisa KATO
DOI: 10.3177/JNSV.48.65
关键词: Azoxymethane 、 Nitric oxide 、 B vitamins 、 Oxidative stress 、 Pyridoxine 、 Micronutrient 、 Biology 、 Nitric oxide synthase 、 Internal medicine 、 Endocrinology 、 Anticarcinogen
摘要: Recently we reported that the supplementation of vitamin B6 to low diet caused suppression in colon tumorigenesis and cell proliferation azoxymethanetreated mice a dose-dependent manner among 1, 7, 14mg pyridoxine HCl/kg (J Nutr 131: 2204-2207, 2001). To examine mechanism anticolon tumor effect B6, male ICR were fed containing 14, 35 mg for 22 wk simultaneously given weekly injection azoxymethane an initial 10 wk. The (1 HCl/kg) suppressed levels colonic 8-hydroxyguanosine 4-hydroxynonenal in-ducible nitric oxide synthase protein. results suggest preventive vita-min against is at least part mediated by reducing oxidative stress production.
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