Surface Chemistry of Vitamin: Pyridoxal 5′‐Phosphate (Vitamin B6) as a Multifunctional Compound for Surface Functionalization

摘要: Vitamins are non-toxic compounds that perform a variety of biological functions and also available in large quantity. Other than the usage as food supplements, few attempts have been made to use them functional materials. In this study, we report vitamin B6, pyridoxal 5′-phosphate (PLP), is multi-functional molecule for oxide surface chemistry. PLP-immobilized surfaces exhibit superhydrophilicity even hemophilicity, enhancing proliferation, migration, differentiation mammalian cells. Unlike existing molecules used so far modification, PLP has an intrinsic chemical reactivity toward biomacromolecules due presence aldehyde group. fact, RGD peptide covalently tethered onto directly one step without any activation. Furthermore, PLP-functionalized implant device showed rapid bone healing. As B6 FDA approved human usage, chemistry potentially allows fast route functionalized medical devices into clinic.